lex (Allen Covert) is a single, 35-year-old video game tester who lives with his friend Josh (Jonathan Loughran). When Josh wastes their rent money on Filipino hookers, their landlord Yuri (Rob Schneider) evicts them, purposely breaks one of their bongs, and has his movers (Todd Holland and Kevin Nash) trash everything that doesn't belong to them. Now Alex has to find a new place to live. Alex tries to stay with his marijuana dealer Dante (Peter Dante), but cannot do so because Dante is adopting a wild lion to live in the house. Alex spends one night with his co-worker Jeff (Nick Swardson), but Jeff still lives with his parents. After an embarrassing "encounter" with Jeff's mom, in which he is caught masturbating in the bathroom and subsequently ejaculates on her, Alex is forced to move in with his grandmother Lilly (Doris Roberts) and her two eccentric friends, Bea (Shirley Knight) and Grace (Shirley Jo nes). Alex is given many chores and fix-up projects to do around the house, but has a hard time completing them because his grandmother and her friends are a constant distraction. He also finds it hard to get any work done. Alex discovers that the three women have a fascination with the television program Antiques Roadshow and later is able to get some work finished by giving them tickets to attend a taping of the show. At work, Alex meets the beautiful Samantha (Linda Cardellini), who has been sent by the company's corporate office to oversee the production of a new video game. Alex and Samantha hit it off, but the only person in the way of their relationship is the creator of the game they are all working on, J.P. (Joel Moore), a self-proclaimed "genius" who is obsessed with video games and has a crush on Samantha. Samantha is not interested in J.P. and declines his constant advances. Meanwhile, in an attempt to sound cool to his younger co-workers (Jonah Hill and Ke lvin Yu), Alex says that he is living "with three hot babes". Alex's friends believe the lie and actually think the reason he is so tired every day at work is because he is living with three women who constantly "wear him out" in the bedroom. The real cause of his fatigue is because he stays up late at night working on his own video game called Demonik which he has been developing in secret for some time. Lilly asks about the game one night and he teaches her to play it. To his surprise, she becomes quite good at it and beats many levels. After Alex and his co-workers finish successfully testing Eternal Death Slayer 3, their boss Mr. Cheezle (Kevin Nealon) tells Samantha to take the boys out to eat at a vegan restaurant, but they instead make fun of the restaurant and their waiter Shilo (David Spade) when they arrive, and then leave to a burger shop. When Jeff has to use the bathroom and refuses to use the one in the restaurant, Alex is forced to take everyon e to his house. Alex comes home to find that Lilly, Grace, and Bea drank all of his pot, which they thought was tea. When Samantha admits to smoking weed too, Alex calls up Dante and throws a wild party. During the party, the group prank-calls J.P. and leaves him a voicemail that makes fun of him about wanting to be a robot. J.P. is upset by the message and shows up at Lilly's house a couple nights later in tears. Feeling bad for him, Alex agrees to let him borrow his only copy of Demonik and test it out for a few days. In retaliation for Alex making his life miserable, and having become accustomed to stealing others' ideas, J.P. steals the game and tries to pass it off as his own at work. Mr. Cheezle does not believe Alex when he insists the game is his since it was his only copy, so his friends call Lilly to the office. Because she has mastered the game already, she plays J.P. and wins to prove it belongs to Alex. J.P. is fired by Mr. Cheezle while Alex is vindicated and c reates a successful game. Alex and Samantha start dati