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ception of human reaction to an external stimulus being mediated by a biological interface (such as a nerve) is nearly as old as the philosophical discipline of science itself. Enlightenment thinkers like René Descartes proposed that the reflexive response to pain, for example, is carried by some sort of fiber—what we would recognize as part of the nervous system today—up to the brain, where it is then processed as the subjective experience of pain. However, this biological stimulus-response reflex was thought by Descartes and others as occurring instantaneously, and therefore not subject to objective measurement.

The first documentation of human reaction time as a scientific variable would come several centuries later, from practical concerns that arose in the field of astronomy. In 1820, German astronomer Friedrich Bessel applied himself to the problem of accuracy in recording stellar transits, which was typically done by using the ticking of a metronome to estimate the time at which a star passed the hairline of a telescope. Bessel noticed timing discrepancies under this method between records of multiple astronomers, and sought to improve accuracy by taking these individual differences in timing into account. This led to various astronomers to seek out ways to minimize these differences between individuals, which came to be known as the "personal equation" of astronomical timing. This phenomenon was explored in detail by English statistician Karl Pearson, who designed one of the first apparatuses to meas

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